NLRP3 Inflammasome activation model

Target neuroinflammation in Parkinson’s disease by studying the therapeutic effects on the NLRP3 pathway activation using the NLRP3 inflammasome activation model

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Home » Neurology CRO Services » Parkinson’s Disease Mouse Models » Parkinson’s models – NLRP3 Inflammasome activation model

Parkinson’s disease (PD) is a neurodegenerative disorder that affects the motor systems in early stages, leading to symptoms such as trembling, slowing of movement, and muscle stiffness. The distinct disease mechanism can be modelled in different mouse models of PD.  

Neuroinflammation plays a key role in the pathophysiology of PD, whereby NLRP3 inflammasome activation represents the key component of neuroinflammation. 

At InnoSer, we detect neuroinflammation in multiple in vivo PD models. Take advantage of InnoSer’s expertise, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience with detecting and analyzing neuroinflammation in in vivo PD models and help guide your decision on choosing the best model fit for your current research goals.
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Studying NLPR3 activation in vivo:

  • MPTP administration leads to robust inflammation in the substantia nigra (SN).

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Belgian based preclinical neurology CRO mouse models

Key readouts

Test the efficacy of your treatments in the following battery of behavioural tests:

Behavioural tests catalogue
Test the efficacy of your treatments with the following biological readouts:

  

  • (Digital) histopathology 
  • Immunohistochemistry (dopamine neurons, neuroinflammation)
  • Immunofluorescence and FISH

Mice injected with MPTP have robust inflammasome activation in the substantia nigra (SN), as detected by fluorescence immunohistochemistry (IHC)

Iba1 signal (red) shows microgliosis. Asc signal (green) staining shows NLRP3 inflammasome activation. Asc signal co-localizes with Iba1-positive microglia (overlay). Nuclei (blue) were detected by DAPI.

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AAALAC Accreditation

InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.

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Animal Welfare

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