Inflammasome NLRP3 activation model
Target neuroinflammation in Parkinson’s disease by studying the therapeutic effects on the NLRP3 pathway activation in vivo
Neuroinflammation plays a key role in the pathophysiology of PD, whereby NLRP3 inflammasome activation represents the key component of neuroinflammation.
Studying NLPR3 activation in vivo:
- MPTP administration leads to robust inflammation in the substantia nigra (SN).
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Test the efficacy of your treatments in the following battery of behavioural tests:
- (Digital) histopathology
- Immunohistochemistry (dopamine neurons, neuroinflammation)
- Immunofluorescence and FISH
Mice injected with MPTP have robust inflammasome activation in the substantia nigra (SN), as detected by fluorescence immunohistochemistry (IHC)
Iba1 signal (red) shows microgliosis. Asc signal (green) staining shows NLRP3 inflammasome activation. Asc signal co-localizes with Iba1-positive microglia (overlay). Nuclei (blue) were detected by DAPI.
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