Inflammasome NLRP3 activation model

Target neuroinflammation in Parkinson’s disease by studying the therapeutic effects on the NLRP3 pathway activation in vivo

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Parkinson’s disease (PD) is a neurodegenerative disorder that affects the motor systems in early stages, leading to symptoms such as trembling, slowing of movement, and muscle stiffness. The distinct disease mechanism can be modelled in different mouse models of PD.  

Neuroinflammation plays a key role in the pathophysiology of PD, whereby NLRP3 inflammasome activation represents the key component of neuroinflammation. 

At InnoSer, we detect neuroinflammation in multiple in vivo PD models. Take advantage of InnoSer’s expertise, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience with detecting and analyzing neuroinflammation in in vivo PD models and help guide your decision on choosing the best model fit for your current research goals.

Studying NLPR3 activation in vivo:

  • MPTP administration leads to robust inflammation in the substantia nigra (SN).

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Belgian based preclinical neurology CRO mouse models

Key readouts

Test the efficacy of your treatments in the following battery of behavioural tests:

Test the efficacy of your treatments with the following biological readouts:


  • (Digital) histopathology 
  • Immunohistochemistry (dopamine neurons, neuroinflammation)
  • Immunofluorescence and FISH

Related Parkinson’s Disease model options

MPTP Induced PD Models

InnoSer offers unique services using MPTP-based inducible PD models.

Transgenic Alpha-Synuclein Models

InnoSer offers fee-for-service transgenic α-syn mouse models.

Seeding Alpha-Synuclein Models

InnoSer has extensive experience with α-syn seeding using both PD patient-derived brain extracts and recombinant seeds.

AAALAC Accreditation

InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.


Animal Welfare

The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why Innoser has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.

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