6-OHDA lesion model

Target dopaminergic cell loss in an inducible 6-OHDA based Parkinson’s Disease model

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Home » Neurology Research Models and Services  » Parkinson’s models and services » Parkinson’s models – 6-OHDA lesion model
Parkinson’s disease (PD) is a neurodegenerative disorder that affects the motor systems in early stages, leading to symptoms such as trembling, slowing of movement, and muscle stiffness. The distinct disease mechanism can be modelled in different mouse models of PD. 

Degeneration of dopaminergic cells in the substantia nigra (SN) is the primary cause of motor symptoms in PD. Stereotaxic injection of 6-OHDA into the SN selectively kills dopamine-producing neurons and is a particularly robust model in rats. 

InnoSer has extensive preclinical research experience with the administration of neurotoxic compounds to induce PD model phenotypes in vivo.  Take advantage of InnoSer’s expertise, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience with modelling PD in vivo and are helping guide your decision on choosing the best model fit for your current research goals. 
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6-OHDA lesion models that InnoSer offers:

  • Available in mice and rats.
  • Can be combined with other PD models (e.g., LRRK2, GBA).

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Neurology platform overview
Belgian based preclinical neurology CRO mouse models

Key readouts

Test the efficacy of your treatments in the following battery of behavioural tests:

  • Spontaneous Behavior (PhenoTyper) 
  • Neurological scoring 
  • Rotarod 
  • Balance beam  
  • Catwalk 
  • Grip strength 
  • Wire hanging 
  • Nest building
Behavioural tests catalogue
Test the efficacy of your treatments with the following biological readouts: 

  • (Digital) histopathology 
  • Immunohistochemistry (dopamine neurons, neuroinflammation) 
  • Immunofluorescence and FISH

Tyrosine hydroxylase (TH) staining can be used to assess dopaminergic cell loss after localized lesions in the substantia nigra (SN)

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AAALAC Accreditation

InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.

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Animal Welfare

The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why InnoSer has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.

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