6-OHDA lesion model
Target dopaminergic cell loss in an inducible 6-OHDA based Parkinson’s Disease model
Degeneration of dopaminergic cells in the substantia nigra (SN) is the primary cause of motor symptoms in PD. Stereotaxic injection of 6-OHDA into the SN selectively kills dopamine-producing neurons and is a particularly robust model in rats.
6-OHDA lesion models that InnoSer offers:
- Available in mice and rats.
- Can be combined with other PD models (e.g., LRRK2, GBA).
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Test the efficacy of your treatments in the following battery of behavioural tests:
- Spontaneous Behavior (PhenoTyper)
- Neurological scoring
- Balance beam
- Grip strength
- Wire hanging
- Nest building
- (Digital) histopathology
- Immunohistochemistry (dopamine neurons, neuroinflammation)
- Immunofluorescence and FISH
Tyrosine hydroxylase (TH) staining can be used to assess dopaminergic cell loss after localized lesions in the substantia nigra (SN)
Related Parkinson’s Disease model options
MPTP Induced PD Models
Transgenic Alpha-Synuclein Models
Seeding Alpha-Synuclein Models
InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.
The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why InnoSer has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.
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