Transgenic SOD1 Models
Develop novel targeted Amyotrophic lateral Sclerosis (ALS) therapies by modelling early-stage symptomatic ALS with SOD1 mutations models
InnoSer offers unique contract research services using several in vivo ALS models, including mutations in the SOD1 gene. Mice that express the human protein with ALS-related mutation have significant SOD1 aggregation, oxidative stress, and motor neuron loss. InnoSer has detected significant motor impairment in transgenic SOD1 mice. Behavioral changes can be detected already at young ages in SOD1 mice and are progressive.
Take advantage of InnoSer’s preclinical research expertise, flexibility, and collaborative approach for your research. We support our clients in identifying new drugs or applications, characterizing their pharmacological properties, and conducting safety and efficacy testing with state-of-the-art readout capabilities and histopathological analysis.
SOD1 model key characteristics:
- Successful validation of multiple SOD1 models.
- Early-onset of motor impairment.
- Behavioural changes can be detected already at young ages in SOD1 mice and are progressive, making this model a valuable tool for efficacy testing of novel compounds.
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Test the efficacy of your treatments in the following battery of behavioural tests:
- Spontaneous Behavior (PhenoTyper)
- Neurological scoring
- Balance beam
- Grip strength
- Wire hanging
- Nest building
- MSD (e.g.,cytokines)
- Immunohistochemistry (e.g,. SOD1 aggregates, neuromuscular junction)
- Immunofluorescence and FISH
SOD1 mutant mice show progressive behavioural changes in the automatic home cages (PhenoTyper™) including a reduced frequency to climb on top of their shelter
SOD1 mice show decrease in motor performance assessed by rotarod
The Rotarod is the golden standard of assessing motor performance and learning in mice. The mice are placed on a rotating rod, with increasing rotating speed. Motor performance is measured by the maximal RPM (rounds per minute) at which mice can keep up with the rotating rod. Motor learning can be assessed by training mice on the rod for several trials.
Related ALS Disease model options
Neurology Platform Overview
Transgenic TDP-43 Models
TDP-43 Seeding Models
InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.
The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why Innoser has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.
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