TDP43 Seeding Mouse Models

Recapitulate the key structural features and spreading of TDP-43 proteinopathy found in the brain of ALS patients

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Amyotrophic lateral sclerosis (ALS) exists on a continuum with frontotemporal dementia (FTD), which also affects the frontal and temporal lobes. It is increasingly recognized that the spreading of TDP-43 plays a key role in the pathophysiology of ALS and FTD. 

Injection of brain extracts from these diseases in the brain of mice closely mimics the structural features of the TDP-43 aggregates found in patients and allows studying of TDP-43 spreading as a therapeutic readout.

InnoSer has extensive experience with seeding-based ALS mouse models, based on both recombinant and patient-derived seeds. Brain extracts from other FTD patients can also be used, mimicking the unique disease pathophysiology.  The choice of the patient brain source depends on the disease of interest. 

Take advantage of InnoSer’s preclinical contract research expertise in modelling TDP-43 pathology, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience working with seeding-based ALS, but also other neurodegenerative disease models. We are happy to help guide your decision on study design fit for your current research goals. 

TDP43 Seeding Mouse Model key model characteristics:

  • Recombinant and patient-derived TDP-43 brain extract seeds are available.
  • TDP-43 aggregates can be injected in both wild-type (WT) or transgenic mice.

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Belgian based preclinical neurology CRO mouse models

Key readouts

Test the efficacy of your treatments in the following battery of behavioural tests:

Test the efficacy of your treatments with the following biological readouts:

  • Immunohistochemistry (TDP-43 accumulation, neuroinflammation) 
  • Immunofluorescence and FISH

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Neurology Platform Overview

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Transgenic SOD1 Models

InnoSer offers unique behavioural research services with several different transgenic SOD1 mouse models.

Transgenic TDP-43 Models

InnoSer offers several transgenic TDP-43 mouse models that recapitulate key structural features and spreading of TDP-43 proteinopathy. 

AAALAC Accreditation

InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.


Animal Welfare

The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why Innoser has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.

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