TDP–43 Seeding Mouse Models
Recapitulate the key structural features and spreading of TDP-43 proteinopathy found in the brain of ALS patients using TDP-43 Seeding Mouse Models
TDP-43 seeding mouse models are established by injecting brain extracts from patients affected by TDP-43 proteinopathy. TAR DNA binding protein (TDP-43) encoded by TARDBP gene, is a major protein involved in the pathogenesis of Amyothropic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Therefore, injection of brain extracts from these diseases in the brain of mice closely mimics the structural features of TDP-43 aggregates found in patients, and allows studying the pathologic spreading of TDP-43 in response to novel compounds as a therapeutic readout.
As part of our specialised preclinical research services, InnoSer offers research services including efficacy studies in TDP-43 seeding mouse models, using either recombinant and/or patient-derived seeds. Accordingly, brain extracts from both ALS and FTD patients can be used, mimicking the unique disease pathophysiology, with the choice of the brain source extracts ultimately depending on your target disease of interest.
Take advantage of InnoSer’s preclinical contract research expertise in modelling TDP-43 pathology, flexibility, and collaborative approach for your research. Our in-house neurology experts have long-standing experience working with seeding-based ALS, but also other neurodegenerative disease models. We are happy to help guide your decision on study design fit for your current research goals.
As part of InnoSer’s neurology ALS mouse model portfolio, we also offer efficacy studies in mouse models with TDP-43 pathology, including transgenic TDP-43 mouse models, as well as a SOD1-G93A transgenic ALS mouse model. However, as each model is unique, modelling distinct pathophysiological aspects of ALS, we recommend you discuss the most appropriate model with our neurology study directors.
TDP–43 Seeding Mouse Model key model characteristics:
- Recombinant and patient-derived TDP-43 brain extract seeds are available.
- TDP-43 aggregates can be injected in both wild-type (WT) or transgenic mice.
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Key readouts
Test the efficacy of your treatments in the following battery of behavioural tests:
- Immunohistochemistry (TDP-43 accumulation, neuroinflammation)
- Immunofluorescence and FISH
Related ALS Disease model options
Neurology Platform Overview
SOD1-G93A Transgenic ALS Mouse Model
InnoSer offers unique behavioural research services with several different transgenic SOD1 mouse models.
TDP-43 Transgenic Mouse Model
InnoSer offers several transgenic TDP-43 mouse models that recapitulate key structural features and spreading of TDP-43 proteinopathy.
AAALAC Accreditation
InnoSer has earned the AAALAC accreditation, demonstrating our commitment to responsible animal care and use. AAALAC International is a nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. Our accreditation is valid for three years, incl. 2023. Read more about the AAALAC accreditation programme here.
Animal Welfare
The 3Rs impact everything from policy and regulatory change to the development and uptake of new technologies and approaches. This is why Innoser has ongoing commitment and monitoring of these processes. The steps we practice maximize our ability to replace, reduce and refine animal involvement and facilitate our commitment to these principles when it comes to research and drug development.
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