To date, large ongoing efforts are being made to provide well-characterised animal models which are suitable for investigating novel therapeutics. To ensure full confidence in the efficacy profile of novel therapeutic agents, efficacy testing often needs to be...
The application of bioluminescence imaging (BLI) in preclinical research studies offers quantitative, sensitive, longitudinal real-time data and can be applied in: Validation of cancer cell lines, helping to establish improved preclinical cancer mouse models. ...
The kidneys of autosomal dominant polycystic kidney disease (ADPKD) patients progressively enlarge due to the formation and expansion of fluid-filled cysts. However, currently there is no available therapy for ADPKD patients that targets the growth of cysts,...
Preclinical Nephrology Research Preclinical studies aiming to assess kidney function in animal models of kidney disease or in response to a test compound have traditionally included readouts such as serum creatinine and blood urea nitrogen (BUN). However, the use of...
Vanishing White Matter (VWM) disease is a rare and fatal leukodystrophy, caused by recessive mutations in the five genes encoding the protein complex eukaryotic translation initiation factor 2B (eIF2B). eIF2B plays a crucial role in initiating and regulating the...
Although multiple kidney disease models have been described in literature, not all of the models are well-characterized and suitable for preclinical research. To help accelerate the development of new drugs to improve the quality of life of patients living with a...
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