Characterization of a transgenic TDP-43 Mouse Model

Characterization of a transgenic TDP-43 Mouse Model

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of upper and lower motoneurons. This leads to brain degeneration and muscle denervation, resulting in extensive muscle atrophy and functional motor impairments....
Characterization of a Spinal Cord Injury (SCI) Mouse Model

Characterization of a Spinal Cord Injury (SCI) Mouse Model

Spinal cord injury (SCI) is a condition mainly resulting from traumatic injuries caused by falls, or (road traffic) accidents. Currently, many novel therapeutics ranging from small molecules, (stem) cell transplants to medical devices are evaluated for their efficacy...
Relevant pharmaco-EEG in vivo data (Baclofen, Fenfluramine)

Relevant pharmaco-EEG in vivo data (Baclofen, Fenfluramine)

Currently, preclinical neuroscience research calls for more translationally relevant biomarkers that help better predict clinical outcomes. Electrophysiological events recorded via electroencephalography (EEG) recordings, highly utilised in the clinic, arise as...
eIF2B Modulators in Vanishing White Matter

eIF2B Modulators in Vanishing White Matter

Vanishing White Matter (VWM) disease is a rare and fatal leukodystrophy, caused by recessive mutations in the five genes encoding the protein complex eukaryotic translation initiation factor 2B (eIF2B). eIF2B plays a crucial role in initiating and regulating the...