Effect of Salsalate on ADPKD progression in the ADPKD Mouse Model

Effect of Salsalate on ADPKD progression in the ADPKD Mouse Model

In this newsletter we present in-house validation data of Salsalate on disease progression in the ADPKD mouse model. One of key therapeutic strategies undertaken to provide new and efficacious treatments for ADPKD is targeting key signaling pathways that drive cystic...
Effect of Salsalate on ADPKD progression in the ADPKD Mouse Model

Assessment of Disease Progression in the ADPKD Mouse Model

A significant challenge in the ADPKD research field is demonstrating efficacy of novel compounds in preclinical research models using clinically relevant endpoints. To date, total kidney volume (TKV) is the only FDA and EMA-approved imaging biomarker that is used as a...
Effect of Salsalate on ADPKD progression in the ADPKD Mouse Model

PK/PD and Tolerability Testing in the ADPKD Mouse Model

The lead optimisation phase is a crucial process during which you investigate and select the most promising preclinical candidate(s) to progress to efficacy testing using animal models of human diseases. Pharmacokinetic (PK) and Pharmacodynamic (PD) profiling helps...
Effect of Salsalate on ADPKD progression in the ADPKD Mouse Model

The Application of Cystic Index in the ADPKD Mouse Model 

The kidneys of autosomal dominant polycystic kidney disease (ADPKD) patients progressively enlarge due to the formation and expansion of fluid-filled cysts. However, currently there is no available therapy for ADPKD patients that targets the growth of cysts,...