Tumor microenvironment (TME) multiplex immunophenotyping analyses

Tumor microenvironment (TME) multiplex immunophenotyping analyses

The use of preclinical orthotopic tumors to better recapitulate the tumor microenvironment (TME) Complex interactions between the cellular and structural components of the tumor microenvironment (TME) composed of tumor cells, fibroblasts, endothelial cells, immune...
Characterization of a Spinal Cord Injury (SCI) Mouse Model

Characterization of a Spinal Cord Injury (SCI) Mouse Model

Spinal cord injury (SCI) is a condition mainly resulting from traumatic injuries caused by falls, or (road traffic) accidents. Currently, many novel therapeutics ranging from small molecules, (stem) cell transplants to medical devices are evaluated for their efficacy...
Relevant pharmaco-EEG in vivo data (Baclofen, Fenfluramine)

Relevant pharmaco-EEG in vivo data (Baclofen, Fenfluramine)

Currently, preclinical neuroscience research calls for more translationally relevant biomarkers that help better predict clinical outcomes. Electrophysiological events recorded via electroencephalography (EEG) recordings, highly utilised in the clinic, arise as...
Effect of Salsalate on ADPKD progression in the ADPKD Mouse Model

Effect of Salsalate on ADPKD progression in the ADPKD Mouse Model

In this newsletter we present in-house validation data of Salsalate on disease progression in the ADPKD mouse model. One of key therapeutic strategies undertaken to provide new and efficacious treatments for ADPKD is targeting key signaling pathways that drive cystic...
Relevant in vivo studies and in vitro immuno-oncology assays

Relevant in vivo studies and in vitro immuno-oncology assays

Drug efficacy in vivo studies  At InnoSer, we frequently carry out in vivo efficacy studies in a range of preclinical models (patient-derived xenografts, syngeneic models, cell-line derived xenografts) complemented with readouts such immune cell profiling and...
Effect of Salsalate on ADPKD progression in the ADPKD Mouse Model

Assessment of Disease Progression in the ADPKD Mouse Model

A significant challenge in the ADPKD research field is demonstrating efficacy of novel compounds in preclinical research models using clinically relevant endpoints. To date, total kidney volume (TKV) is the only FDA and EMA-approved imaging biomarker that is used as a...