CognitionWall™ Discrimination Learning
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice (Remmelink et al. 2016), without the time-consuming handling of mice. Mice are rewarded with food when they choose to pass through one of the three entrances of the CognitionWall™.
The rate at which a mouse gains preference for the entrance containing the food is used as a measure of discrimination learning. The discrimination learning is an automated home cage testing protocol that works with automatic cages (PhenoTyper™), a video monitoring system and automatic data analysis system (AHCODA™).
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
The CognitionWall™ is a wall with three entrances in front of a food dispenser. Mice are rewarded with a food reward when they choose to pass through one of the three entrances. The rate at which a mouse gains a relative preference for the rewarded entrance is used as a measure of discrimination learning.
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
Mouse models of AD show an impaired cognitive performance during the CognitionWall™ Discrimination learning. This deficit is already apparent at 12 weeks of age, before the appearance of plaques (~26 weeks). At 16 weeks, this deficit in discrimination learning can be rescued by an acute dose of the BACE1 inhibitor LY2886721.
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
Mice injected with a low dose of MK-801 show robust cognitive deficits in the CognitionWall discrimination learning task in the PhenoTyper™.
The CognitionWall™ is a one-night automated test to efficiently identify discrimination learning impairments in mice.
Fmr1 KO mice require more entries to reach a performance of 90% correct entries in the CognitionWal™ discrimination learning task in comparison with WT littermates, both 6 weeks of age as shown and at 12 weeks of age (not shown).
Most commonly used in combination with:
- Neuropsychiatric models
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