Relevant pharmaco-EEG in vivo data (Baclofen, Fenfluramine)

Relevant pharmaco-EEG in vivo data (Baclofen, Fenfluramine)

Currently, preclinical neuroscience research calls for more translationally relevant biomarkers that help better predict clinical outcomes. Electrophysiological events recorded via electroencephalography (EEG) recordings, highly utilised in the clinic, arise as...
Effect of Salsalate on ADPKD progression in the ADPKD Mouse Model

Effect of Salsalate on ADPKD progression in the ADPKD Mouse Model

In this newsletter we present in-house validation data of Salsalate on disease progression in the ADPKD mouse model. One of key therapeutic strategies undertaken to provide new and efficacious treatments for ADPKD is targeting key signaling pathways that drive cystic...
Relevant in vivo studies and in vitro immuno-oncology assays

Relevant in vivo studies and in vitro immuno-oncology assays

Drug efficacy in vivo studies  At InnoSer, we frequently carry out in vivo efficacy studies in a range of preclinical models (patient-derived xenografts, syngeneic models, cell-line derived xenografts) complemented with readouts such immune cell profiling and...
Effect of Salsalate on ADPKD progression in the ADPKD Mouse Model

Assessment of Disease Progression in the ADPKD Mouse Model

A significant challenge in the ADPKD research field is demonstrating efficacy of novel compounds in preclinical research models using clinically relevant endpoints. To date, total kidney volume (TKV) is the only FDA and EMA-approved imaging biomarker that is used as a...