• β-amyloid plaques are observed in the cortex, hippocampus and subiculum from an age of 8 months
• Tau pathology is observed in the cortex, hippocampus, subiculum and brainstem from an age of 8 months
• Astrocytosis and microgliosis are observed in the cortex and subiculum from an age of 9 months
• Cognitive impairment in Morris water maze paradigm from an age of 6.5 months
• Progressive motoric impairment from an age of 9 months

Progressive accumulation of plaque deposition (LOC), hyperphosphorylated Tau (AT100 = pThr212/pSer214 Tau), astrocytosis (GFAP) and microgliosis (CD45) in the cortex as measured by IHC (mean ± SEM, n = 8, no data for WT at 11.2 months). Statistics: One-Way ANOVA, Tukey’s multiple comparison.

Adjacent brain section of a single mouse at 13 months of age of Aβ, Tau and inflammatory markers.

Progressively lower Aβ42/40 in plasma correlates with Aβ plaques in the cortex (mean ± SEM, n = 7 or 8). Plasma Aβ concentration were measured using MSD-technology (kit K15200E). A significant negative correlation is observed between the plasma Aβ42/40 ratio and Aβ pathology in the cortex. Statistics: One-Way ANOVA, Tukey’s multiple comparison and Pearson’s r correlation coefficient.